HOME

 
Docking-based focused libraries
Receptor-based target-focused librariesOur company offers unique docking-based target-focused libraries. They are produced based on computational estimation of compounds’ interaction with one specific member in a protein family (sharpfocusing approach). Each library contains about 2,000 compounds selected from OTAVA’s collection of 500,000 in-stock compounds. Our proprietary method for receptor-based virtual screening of compounds includes powerful combination of drug-likeness filtering, molecular docking, re-scoring, key intermolecular hydrogen bond detection and,finally, visual inspection of ligand-receptor complexes.

READ MORE about design approach



[TARGET]

[SOURCE]

[SOURCE LIBRARIES]

[INFO]

[NUMBER OF COMPOUNDS]

P21-Activated Kinase 1 (PAK1)

Homo Sapiens
Otava and Life Chemicals Stock  Collections 500,000 cmpds

more>>

2024

 Serine/Threonine-Protein Kinase CHK1
(CHK1)
 Homo Sapiens  Otava and Life Chemicals Stock  Collections 500,000 cmpds more>>  1946

Proto-Oncogene Tyrosine-Protein Kinase ABL1

Homo Sapiens
Otava and Life Chemicals Stock  Collections 500,000 cmpds

more>>

2048

 Extracellular Signal-Regulated Kinase 2
(ERK2)
 Homo Sapiens  Otava and Life Chemicals Stock  Collections 500,000 cmpds more>>  2053

Death-Associated Protein Kinase 2
(DAPK-2)

Homo Sapiens
Otava and Life Chemicals Stock  Collections 500,000 cmpds

more>>

2012

p38 MAP Kinase Alpha

Homo Sapiens
Otava and Life Chemicals Stock  Collections 400,000 cmpds

more>>

2221

Vascular Endothelial Growth Factor Receptor 2
(VEGFR2)

Homo Sapiens
Otava and Life Chemicals Stock  Collections 400,000 cmpds

more>>

2235

Aurora B kinase

Xenopus Laevis
Otava and Life Chemicals Stock  Collections 400,000 cmpds

more>>

2069

Janus Kinase 2
(Jak2)

Homo Sapiens
Otava and Life Chemicals Stock  Collections 400,000 cmpds

more>>

2190

Phosphatidylinositol 3-kinase
(PI3K)

Homo Sapiens
Otava and Life Chemicals Stock  Collections 400,000 cmpds

more>>

2040

3-phosphoinositide-dependent kinase-1
(PDK-1)

Homo Sapiens
Otava and Life Chemicals Stock  Collections 400,000 cmpds

more>>

1975


Estrogen Receptor (Alpha)

Homo Sapiens
Otava Stock Collection 70,000 cmpds

more>>

935

Cyclin Dependent
Kinase 2
(CDK2)

Homo Sapiens
Otava Stock Collection 70,000 cmpds

more>>

1281

Glycogen Synthase Kinase-3 (GSK3)

Homo Sapiens
Otava Stock Collection 70,000 cmpds

more>>

980

Acetylcholinesterase (AChE)

Homo sapiens
Otava Stock Collection 70,000 cmpds

more>>

828

Phospholipase A2
(PLA(2))

Homo Sapiens
Otava Stock Collection 70,000 cmpds

more>>

1018

Fibroblast growth factor receptor 1 tyrosine kinase (FGFR1K)

Homo Sapiens
Otava and Life Chemicals Stock  Collections 400,000 cmpds

more>>

1761

cAMP dependent protein kinase (PKA)

Mus Musculus
Otava and Life Chemicals Stock  Collections 400,000 cmpds

more>>

1877