Electrochemical screening of the indole/quinolone derivatives as potential protein kinase CK2 inhibitors
     
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Electrochemical screening of the indole/quinolone derivatives as potential protein kinase CK2 inhibitors

New publication: Electrochemical screening of the indole/quinolone derivatives as potential protein kinase CK2 inhibitors

OTAVAchemicals has published new scientific paper on CK2 inhibitors. 

Abstract: An electrochemical method based on the bioorganometallic Fc-ATP cosubstrate for kinase-catalyzed phosphorylation reactions was used for monitoring casein kinase 2 (CK2) phosphorylations in the absence and presence of ?ve indole/quinolone-based potential inhibitors.  Fc-phosphorylation of immobilized peptide RRRDDDSDDD on Au surfaces resulted in a current density at approximately 460 10 mV. An electrochemical redox signal was signi?cantly decreased in the presence of inhibitors. In addition, the electrochemical signal was concentration dependent with respect to the potential inhibitors 1 to 5, which proved to be viable CK2 drug targets with estimated IC50 values in the nanomolar range.

PubMed PMID: 22178909

 
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