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Electrochemical screening of the indole/quinolone derivatives as potential protein kinase CK2 inhibitors

New publication: Electrochemical screening of the indole/quinolone derivatives as potential protein kinase CK2 inhibitors

 

OTAVAchemicals has published new scientific paper on CK2 inhibitors. 

Abstract: An electrochemical method based on the bioorganometallic Fc-ATP cosubstrate for kinase-catalyzed phosphorylation reactions was used for monitoring casein kinase 2 (CK2) phosphorylations in the absence and presence of five indole/quinolone-based potential inhibitors.  Fc-phosphorylation of immobilized peptide RRRDDDSDDD on Au surfaces resulted in a current density at approximately 460 ± 10 mV. An electrochemical redox signal was significantly decreased in the presence of inhibitors. In addition, the electrochemical signal was concentration dependent with respect to the potential inhibitors 1 to 5, which proved to be viable CK2 drug targets with estimated IC50 values in the nanomolar range.

PubMed PMID: 22178909

 
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