Home > News > Product Spotlights > New biologically active molecules in milligram quantities
New biologically active molecules in milligram quantities

New biologically active molecules in milligram quantities

The sigma-1 receptor is a transmembrane protein expressed in many different tissue types. It is particularly concentrated in certain regions of the central nervous system. It has been implicated in myriad phenomena, including cardiovascular function, schizophrenia, clinical depression, the effects of cocaine abuse, and cancer. Much is known about the binding affinity of hundreds of synthetic compounds to the sigma-1 receptor.

The alpha-7 nicotinic receptor, also known as the ?7 receptor, is a type of nicotinic acetylcholine receptor, consisting entirely of ?7 subunits. Recent work has demonstrated its potential role in reducing inflammatory neurotoxicity in stroke, MI, sepsis, and Alzheimer's disease.

Acetyl-CoA acetyltransferase is an enzyme that in humans is encoded by the ACAT1 (Acetyl-Coenzyme A acetyltransferase 1) gene. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.

Janus kinase 3 is a tyrosine kinase that belongs to the Janus family of kinases. Activating mutations in JAK1, JAK2, and JAK3 have been identified as causes of hematological cancers, while inactivating mutations of JAK3 are known causes of immune deficiency.

 
Our company offers various small biologically active molecules which are available in milligram quantities. Custom and bulk quotes are also available. ALL these NEW products are IN-STOCK and they available for immediate delivery:

?1 Receptor Antagonist S1RA [1]

Sigma 1 Receptor Antagonist S1RA

OTAVAchemicals catalogue no. 7070707164

Novel Positive Allosteric Modulator
of the ?-7 Nicotinic Acetylcholine Receptor (A-867744) [2]


Novel Positive Allosteric Modulator of the ?-7 Nicotinic Acetylcholine Receptor (A-867744)

CAS RN 1000279-69-5
OTAVAchemicals catalogue no. 7070707121

Selective ACAT-1 Inhibitor (K-604) [3]

Selective ACAT-1 Inhibitor (K-604)

CAS RN 561023-90-3
OTAVAchemicals catalogue no. 7070707145

Potent JAK3 inhibitor which also inhibits GSK-3?, PKC? and PKC? (TCS 21311) [4]

Potent JAK3 inhibitor which also inhibits GSK-3?, PKC? and PKC? (TCS 21311)

CAS RN 1260181-14-3
OTAVAchemicals catalogue no. 7070707149

  • Compounds are for prompt delivery (by FedEx)
  • Delivery time is 5-9 business days
  • Quality control by NMR and/or GC/LC/MS
  • Purity: 90%+
  • NMR spectra are available upon request
  • Available amounts: milligram and gram quantities
  • Supplied as dry powders
  • Re-synthesis is possible

Please contact us to order these compounds

 

References:

  1. B. Wnsch.  The ?1 Receptor Antagonist S1RA Is a Promising Candidate for the Treatment of Neurogenic Pain.  J. Med. Chem. (2012), 55, 8209-8210
  2. Faghih et al. Discovery of 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a Novel Positive Allosteric Modulator of the r7 Nicotinic Acetylcholine Receptor. J. Med. Chem. (2009), 52, 33773384
  3. Ikenoya et al. A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels. Atherosclerosis 191 (2007) 290297
  4. Thoma et al. Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family. J. Med. Chem. (2010), 54, 284

 
OTAVAchemicals has extensive experience in the synthesis of highly valuable products for biotech and pharmaceutical applications around the world. Our company offers a number of  inhibitors and other biologically active compounds modulating activity of distinct targets. These compounds are available in milligram and gram quantities.

 
See the full list of our Bioactive Small Molecules


 Download Bioactive Small Molecules catalogue (PDF)

 

 
SSL