5-(2-Hydroxy-naphthalen-1-ylmethyl)-6-phenyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

Uncompetitive neutral sphingomyelinase 2 (nSMase2) inhibitor Ki = 7 µM. Nonselective sirtuin inhibitor SIRT1 IC50 = 56 µM and SIRT2 IC50 = 51 µM

OTAVAchemicals Catalogue Number: 7020402315
CAS Registry Number: 14513-15-6
Purity: 99% (HPLC)

Ref.: PLoS ONE 2015, 10, 5, e0124481 J. Med. Chem. 2014, 57, 8, 3283 – 3294

Abstract: Uncompetitive inhibitor of Neutral Sphingomyelinase 2 (nSMase2), expressed in neurons. Increased nSMase2 activity translates into higher ceramide levels and neuronal cell death. Nonselective sirtuins SIRT1 and SIRT2 inibitor 

DOI: 10.1371/journal.pone.0124481 10.1021/jm4018064