4-Amino-N-(4-chlorophenyl)-N-methyl-benzenesulfonamide

OTAVAchemicals Catalogue Number: 7070707001
CAS Registry Number: 304913-22-2
Purity: 96%+ (HPLC)

Ref.: Bioorganic & Medicinal Chemistry 15 (2007) 1014–1021

Abstract: COX-1 Inhibitor II is a cell-permeable benzenesulfonamide compound that targets the catalytic site of Cox (cyclooxygenase). COX-1 Inhibitor II inhibits Cox-1 (IC50 of 3.2 ?M) more selectively than Cox-2 (IC50 of > 100 ?M). Much like Aspirin (sc-202471), COX-1 Inhibitor II has shown similar in vivo analgesic activity, yet unlike Aspirin and Indomethacin, (sc-200503) COX-1 Inhibitor II does not induce gastric disturbance. The compound was revealed to inhibit PCA response in addition to Cox-2 expression and to exert anti-inflammatory effects by suppressing phosphorylation of ERK.

DOI: 10.1016/j.bmc.2006.10.029