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GPCR Targeted Libraries

GPCR focused librariesCurrent advances in functional screening methodologies, medicinal chemistry, and structure-based drug design have generated large increases in the number and diversity of GPCR drug targets. Furthermore, basic research advances have opened the way for still further exploitation of this target class. G protein-coupled receptors (GPCRs) are popular drug targets, accounting for about one-third of approved drugs and many hundreds of drugs currently in development.

 

 

 

 
Otava offers 25 GPCR Targeted Libraries designed with Ligand-based approach. These libraries are proposed for screening in GPCR-associated research and drug development projects.

  • the libraries contain drug-like compounds only
  • all the compounds are in stock
  • cherry picking is available

 

You can sort data by any column and use "Filter" option to search library's name:

Name Number of compounds Approach Details Available on-line
GPCR Agonists 465 Ligand-based Ligand-based Search on-line search on-line
5 Hydroxytryptamine agonist 54 Ligand-based Ligand-based -
Acetylcholine muscarinic agonist 10 Ligand-based Ligand-based -
Alpha adrenoreceptor agonist 45 Ligand-based Ligand-based -
Cholecystokinin agonist 12 Ligand-based Ligand-based -
Dopamine agonist 29 Ligand-based Ligand-based -
Dopamine autoreceptor agonist 181 Ligand-based Ligand-based -
GABA receptor agonist 117 Ligand-based Ligand-based -
Melatonin agonist 17 Ligand-based Ligand-based -
GPCR Antagonists 5089 Ligand-based Ligand-based Search on-line search on-line
5 Hydroxytryptamine antagonist 347 Ligand-based Ligand-based -
Acetylcholine muscarinic antagonist 81 Ligand-based Ligand-based -
Adenosine receptor antagonist 110 Ligand-based Ligand-based -
Alpha adrenoreceptor antagonist 1045 Ligand-based Ligand-based -
Beta adrenoreceptor antagonist 89 Ligand-based Ligand-based -
Dopamine antagonist 61 Ligand-based Ligand-based -
Endothelin receptor antagonist 165 Ligand-based Ligand-based -
GABA receptor antagonist 1133 Ligand-based Ligand-based -
Glucagon receptor antagonist 526 Ligand-based Ligand-based -
Glutamate receptor antagonist 15 Ligand-based Ligand-based -
Histamine antagonist 590 Ligand-based Ligand-based -
Neuropeptide antagonist 106 Ligand-based Ligand-based -
Prostaglandin antagonist 665 Ligand-based Ligand-based -
Thromboxane antagonist 133 Ligand-based Ligand-based -
Vasopressin 1 antagonist 23 Ligand-based Ligand-based Search on-line search on-line
5-Hydroxytryptamine Receptor (5-HT1B) Antagonist 1836 Receptor-based Receptor-Based read more

 

Otava's Target-Focused Libraries distribution chart
Name Number
Kinases 67
Proteases 12
GPCRs 24
Ion channels 3
Disease-based libraries 29
Epigenetic targets 6
Protein-Protein Interaction 2
Peptidomimetic 1
Nuclear Receptors 1
General Activities 127
Other 101

 

Learn more about other Focused Libraries available from Otava:

 

 

 

 

The libraries (DB, SD, XLS, PDF format) as well as price-list are available on request. Feel free to contact us or use on-line form below to send an inquiry if you are interested to obtain these libraries or if you need more information.

 

 

 

 

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