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Protease Targeted Libraries

Protease focused librariesProteases constitute one of the largest potential drug target enzyme families, with 647 human gene products incorporating protease sequences and mutated proteases having been identified. In addition, there are many more proteases found in viruses, bacteria, and parasites, which are also potential drug targets. The therapeutic promise of protease inhibitors has been most clearly demonstrated by angiotensin-converting enzyme (ACE) and HIV drugs. Inhibition of protease activity modulates physiological functions, either by reducing the formation of undesirable peptide mediators or by enhancing the beneficial effects of peptides by preventing their catabolism.

 

 

 
Otava offers 12 Protease Targeted Libraries designed with Ligand-based approach. These libraries are proposed for screening in protease-associated research and drug development projects.

  • the libraries contain drug-like compounds only
  • all the compounds are in stock
  • cherry picking is available

 

You can sort data by any column and use "Filter" option to search library's name:

Name Number of compounds Approach
Trypsin inhibitor 85 Ligand-based
Factor Xa inhibitor 122 Ligand-based
Tryptase inhibitor 139 Ligand-based
Cathepsin B inhibitor 275 Ligand-based
Cathepsin L inhibitor 71 Ligand-based
Cathepsin T inhibitor 1550 Ligand-based
Subtilisin inhibitor 123 Ligand-based
HCV serine protease inhibitor 1300 Ligand-based
Matrix metalloproteinase 1 inhibitor 39 Ligand-based
Matrix metalloproteinase inhibitor 16 Ligand-based
Metalloproteinase inhibitor 21 Ligand-based
Metalloproteinase-9 inhibitor 608 Ligand-based

 

Otava's Target-Focused Libraries collection
Name Number
Kinases 67
Proteases 12
GPCRs 24
Ion channels 3
Disease-based libraries 29
Epigenetic targets 6
Protein-Protein Interaction 2
Peptidomimetic 1
Nuclear Receptors 1
General Activities 127
Other 101

 

 

The libraries (SDF, XLS, PDF format) are available on request. Feel free to contact us or use on-line form below to send an inquiry if you are interested to obtain these libraries or if you need more information.

 

 

 

 

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