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Protease Targeted Libraries

Protease focused librariesProteases constitute one of the largest potential drug target enzyme families, with 647 human gene products incorporating protease sequences and mutated proteases having been identified. In addition, there are many more proteases found in viruses, bacteria, and parasites, which are also potential drug targets. The therapeutic promise of protease inhibitors has been most clearly demonstrated by angiotensin-converting enzyme (ACE) and HIV drugs. Inhibition of protease activity modulates physiological functions, either by reducing the formation of undesirable peptide mediators or by enhancing the beneficial effects of peptides by preventing their catabolism.

 

 

 
Otava offers 12 Protease Targeted Libraries designed with Ligand-based approach. These libraries are proposed for screening in protease-associated research and drug development projects.

  • the libraries contain drug-like compounds only
  • all the compounds are in stock
  • cherry picking is available

 

You can sort data by any column and use "Filter" option to search library's name:

Name Number of compounds Approach Available on-line
Trypsin inhibitor 85 Ligand-based Ligand-based Search on-line search on-line
Factor Xa inhibitor 122 Ligand-based Ligand-based Search on-line search on-line
Tryptase inhibitor 139 Ligand-based Ligand-based Search on-line search on-line
Cathepsin B inhibitor 275 Ligand-based Ligand-based Search on-line search on-line
Cathepsin L inhibitor 71 Ligand-based Ligand-based Search on-line search on-line
Cathepsin T inhibitor 1550 Ligand-based Ligand-based Search on-line search on-line
Subtilisin inhibitor 123 Ligand-based Ligand-based Search on-line search on-line
HCV serine protease inhibitor 1300 Ligand-based Ligand-based Search on-line search on-line
Matrix metalloproteinase 1 inhibitor 39 Ligand-based Ligand-based -
Matrix metalloproteinase inhibitor 16 Ligand-based Ligand-based -
Metalloproteinase inhibitor 21 Ligand-based Ligand-based -
Metalloproteinase-9 inhibitor 608 Ligand-based Ligand-based -

 

Otava's Target-Focused Libraries distribution chart
Name Number
Kinases 67
Proteases 12
GPCRs 24
Ion channels 3
Disease-based libraries 29
Epigenetic targets 6
Protein-Protein Interaction 2
Peptidomimetic 1
Nuclear Receptors 1
General Activities 127
Other 101

 

Learn more about other Focused Libraries available from Otava:

 

 

 

 

The libraries (DB, SD, XLS, PDF format) as well as price-list are available on request. Feel free to contact us or use on-line form below to send an inquiry if you are interested to obtain these libraries or if you need more information.

 

 

 

 

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