Proteases constitute one of the largest potential drug target enzyme families, with 647 human gene products incorporating protease sequences and mutated proteases having been identified. In addition, there are many more proteases found in viruses, bacteria, and parasites, which are also potential drug targets. The therapeutic promise of protease inhibitors has been most clearly demonstrated by angiotensin-converting enzyme (ACE) and HIV drugs. Inhibition of protease activity modulates physiological functions, either by reducing the formation of undesirable peptide mediators or by enhancing the beneficial effects of peptides by preventing their catabolism.

 

 

You can sort data by any column and use "Filter" option to search library's name:

Name	Number of compounds	Approach	Available on-line
Trypsin inhibitor	175	Ligand-based	search on-line
Factor Xa inhibitor	331	Ligand-based	search on-line
Tryptase inhibitor	347	Ligand-based	search on-line
Cathepsin B inhibitor	427	Ligand-based	search on-line
Cathepsin L inhibitor	115	Ligand-based	search on-line
Cathepsin T inhibitor	2438	Ligand-based	search on-line
Subtilisin inhibitor	156	Ligand-based	search on-line
HCV serine protease inhibitor	1307	Ligand-based	search on-line
Matrix metalloproteinase 1 inhibitor	76	Ligand-based	-
Matrix metalloproteinase inhibitor	29	Ligand-based	-
Metalloproteinase inhibitor	70	Ligand-based	-
Metalloproteinase-9 inhibitor	1527	Ligand-based	-

 

 

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