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Protein Kinase Targeted Libraries

Kinase focused librariesProtein kinases constitute a large family of proteins that is now firmly established as a major class of drug targets for the pharmaceutical industry. With so many inhibitors reported to be in clinical development and many more in preclinical development, kinase inhibitors now make up a significant fraction of most major pharmaceutical companies' pipelines, as well as an area of focus for many biotechnology companies. The increased interest in this class of targets reflects both advances in identifying selective protein kinase inhibitors and a growing perception that these drugs offer a novel, well-tolerated oral therapy in some of the most untreatable cancers.

 

 

 
Otava offers 67 Protein Kinase Targeted Libraries designed with Receptor-based or Ligand-based approach. These libraries are proposed for screening in kinasel-associated research and drug development projects.

 

  • the libraries contain drug-like compounds only
  • all the compounds are in stock
  • cherry picking is available

 

You can sort data by any column and use "Filter" option to search library's name:

Name Number of compounds Approach Details Available on-line
1-Phosphatidylinositol-4-phosphate 5-kinase (PIPK) inhibitor 14 Ligand-based Ligand-based - Search on-line search on-line
Abl kinase inhibitor 76 Ligand-based Ligand-based - Search on-line search on-line
Acetate kinase inhibitor 129 Ligand-based Ligand-based - Search on-line search on-line
ADP-thymidine kinase inhibitor 922 Ligand-based Ligand-based - Search on-line search on-line
Aurora kinase inhibitor 364 Ligand-based Ligand-based - Search on-line search on-line
Aurora-B kinase inhibitor 249 Ligand-based Ligand-based - Search on-line search on-line
Aurora-C kinase inhibitor 1162 Ligand-based Ligand-based - Search on-line search on-line
Beta-adrenergic receptor kinase (BARK) inhibitor 1268 Ligand-based Ligand-based - Search on-line search on-line
Check point kinase (CHK) inhibitor 593 Ligand-based Ligand-based - Search on-line search on-line
Cyclin-dependent kinase 1 (CDK1) inhibitor 83 Ligand-based Ligand-based - Search on-line search on-line
Cyclin-dependent kinase 2 (CDK2) inhibitor 905 Ligand-based Ligand-based - Search on-line search on-line
Cyclin-dependent kinase 4 (CDK4) inhibitor 798 Ligand-based Ligand-based - Search on-line search on-line
Cyclin-dependent kinase (CDK) inhibitor 285 Ligand-based Ligand-based - Search on-line search on-line
EphB2 kinase inhibitor 329 Ligand-based Ligand-based - Search on-line search on-line
Epidermal growth factor receptor kinase (EGFR) inhibitor 318 Ligand-based Ligand-based - Search on-line search on-line
Glycogen synthase kinase-3 (GSK3) inhibitor 153 Ligand-based Ligand-based - Search on-line search on-line
G-protein-coupled receptor kinase (GRK) inhibitor 1268 Ligand-based Ligand-based - Search on-line search on-line
Guanidinoacetate kinase inhibitor 254 Ligand-based Ligand-based - Search on-line search on-line
I kappa B kinase 2 (IKK2) inhibitor 347 Ligand-based Ligand-based - Search on-line search on-line
Inositol-trisphosphate 3-kinase (IP3K) inhibitor 78 Ligand-based Ligand-based - Search on-line search on-line
Lombricine kinase inhibitor 163 Ligand-based Ligand-based - Search on-line search on-line
MAP kinase (MAPK) inhibitor 102 Ligand-based Ligand-based - Search on-line search on-line
N-acylmannosamine kinase inhibitor 935 Ligand-based Ligand-based - Search on-line search on-line
NADH kinase inhibitor 871 Ligand-based Ligand-based - Search on-line search on-line
Opheline kinase inhibitor 875 Ligand-based Ligand-based - Search on-line search on-line
Phosphatidylinositol 3-kinase beta (PI3K-C2 beta) inhibitor 1183 Ligand-based Ligand-based - Search on-line search on-line
Phosphatidylinositol 3-kinase gamma (PI3K-C2 gamma) inhibitor 252 Ligand-based Ligand-based - Search on-line search on-line
Phosphoenolpyruvate carboxykinase (PEPCK) inhibitor 26 Ligand-based Ligand-based - Search on-line search on-line
Platelet derived growth factor receptor kinase (PDGFR) inhibitor 1972 Ligand-based Ligand-based - Search on-line search on-line
Protein kinase CK1 inhibitor 1387 Ligand-based Ligand-based - Search on-line search on-line
Protein kinase B (PKB) inhibitor 1030 Ligand-based Ligand-based - Search on-line search on-line
Protein kinase C eta (PKC) inhibitor 16 Ligand-based Ligand-based - Search on-line search on-line
Protein-serine-threonine kinase inhibitor 213 Ligand-based Ligand-based - Search on-line search on-line
Proto-oncogene tyrosine-protein kinase Fyn inhibitor 481 Ligand-based Ligand-based - Search on-line search on-line
Proto-oncogene tyrosine-protein kinase Kit inhibitor 214 Ligand-based Ligand-based - Search on-line search on-line
Pyridoxal kinase inhibitor 5 Ligand-based Ligand-based - Search on-line search on-line
Raf kinase B inhibitor 38 Ligand-based Ligand-based - Search on-line search on-line
Raf kinase inhibitor 74 Ligand-based Ligand-based - Search on-line search on-line
Rho-associated kinase inhibitor 344 Ligand-based Ligand-based - Search on-line search on-line
Ribosomal protein S6 kinase (S6K) inhibitor 10 Ligand-based Ligand-based - Search on-line search on-line
Shikimate kinase inhibitor 453 Ligand-based Ligand-based - Search on-line search on-line
Smooth muscle myosin light chain kinase (MLCK) inhibitor 627 Ligand-based Ligand-based - Search on-line search on-line
Sphinganine kinase inhibitor 244 Ligand-based Ligand-based - Search on-line search on-line
Sphingosine kinase inhibitor 1119 Ligand-based Ligand-based - Search on-line search on-line
Src kinase inhibitor 200 Ligand-based Ligand-based - Search on-line search on-line
Taurocyamine kinase inhibitor 875 Ligand-based Ligand-based - Search on-line search on-line
Thymidine kinase inhibitor 922 Ligand-based Ligand-based - Search on-line search on-line
Tyrosine kinase inhibitor 1147 Ligand-based Ligand-based - Search on-line search on-line
Urokinase inhibitor 21 Ligand-based Ligand-based - Search on-line search on-line
P21-Activated Kinase 1 (PAK1) 2024 Receptor-based Receptor-Based read more Search on-line search on-line
Serine/Threonine-Protein Kinase CHK1 (CHK1) 1946 Receptor-based Receptor-Based read more Search on-line search on-line
Proto-Oncogene Tyrosine-Protein Kinase ABL1 2048 Receptor-based Receptor-Based read more Search on-line search on-line
Extracellular Signal-Regulated Kinase 2 (ERK2) 2053 Receptor-based Receptor-Based read more Search on-line search on-line
Death-Associated Protein Kinase 2 (DAPK-2) 2012 Receptor-based Receptor-Based read more Search on-line search on-line
p38 MAP Kinase Alpha 2221 Receptor-based Receptor-Based read more Search on-line search on-line
Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) 2235 Receptor-based Receptor-Based read more Search on-line search on-line
Aurora B kinase 2069 Receptor-based Receptor-Based read more Search on-line search on-line
Janus Kinase 2 (Jak2) 2190 Receptor-based Receptor-Based read more Search on-line search on-line
Phosphatidylinositol 3-kinase (PI3K) 2040 Receptor-based Receptor-Based read more Search on-line search on-line
3-phosphoinositide-dependent kinase-1 (PDK-1) 1975 Receptor-based Receptor-Based read more Search on-line search on-line
Cyclin Dependent Kinase 2 (CDK2) 1281 Receptor-based Receptor-Based read more Search on-line search on-line
Glycogen Synthase Kinase-3 (GSK3) 980 Receptor-based Receptor-Based read more Search on-line search on-line
Fibroblast growth factor receptor 1 tyrosine kinase (FGFR1K) 1761 Receptor-based Receptor-Based read more Search on-line search on-line
cAMP dependent protein kinase (PKA) 1877 Receptor-based Receptor-Based read more Search on-line search on-line
C-Jun N-Terminal Kinase 2 (Jnk2, Mapk9) 1774 Receptor-based Receptor-Based - Search on-line search on-line
Death-associated protein kinase 1 (DAPK1) 1962 Receptor-based Receptor-Based - Search on-line search on-line
Death-associated protein kinase 3 (DAPK3) 1814 Receptor-based Receptor-Based - Search on-line search on-line

 

Otava's Target-Focused Libraries distribution chart
Name Number
Kinases 67
Proteases 12
GPCRs 24
Ion channels 3
Disease-based libraries 29
Epigenetic targets 6
Protein-Protein Interaction 2
Peptidomimetic 1
Nuclear Receptors 1
General Activities 127
Other 101

 

Learn more about other Focused Libraries available from Otava: 

 

 

 

 

The libraries (DB, SD, XLS, PDF format) as well as price-list are available on request. Feel free to contact us or use on-line form below to send an inquiry if you are interested to obtain these libraries or if you need more information.

 

 

 

 

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