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Protein Kinase Targeted Libraries

Kinase focused librariesProtein kinases constitute a large family of proteins that is now firmly established as a major class of drug targets for the pharmaceutical industry. With so many inhibitors reported to be in clinical development and many more in preclinical development, kinase inhibitors now make up a significant fraction of most major pharmaceutical companies' pipelines, as well as an area of focus for many biotechnology companies. The increased interest in this class of targets reflects both advances in identifying selective protein kinase inhibitors and a growing perception that these drugs offer a novel, well-tolerated oral therapy in some of the most untreatable cancers.

 

 

 
Otava offers 67 Protein Kinase Targeted Libraries designed with Receptor-based or Ligand-based approach. These libraries are proposed for screening in kinasel-associated research and drug development projects.

 

  • the libraries contain drug-like compounds only
  • all the compounds are in stock
  • cherry picking is available

 

You can sort data by any column and use "Filter" option to search library's name:

Name Number of compounds Approach Details
1-Phosphatidylinositol-4-phosphate 5-kinase (PIPK) inhibitor 14 Ligand-based -
Abl kinase inhibitor 76 Ligand-based -
Acetate kinase inhibitor 129 Ligand-based -
ADP-thymidine kinase inhibitor 922 Ligand-based -
Aurora kinase inhibitor 364 Ligand-based -
Aurora-B kinase inhibitor 249 Ligand-based -
Aurora-C kinase inhibitor 1162 Ligand-based -
Beta-adrenergic receptor kinase (BARK) inhibitor 1268 Ligand-based -
Check point kinase (CHK) inhibitor 593 Ligand-based -
Cyclin-dependent kinase 1 (CDK1) inhibitor 83 Ligand-based -
Cyclin-dependent kinase 2 (CDK2) inhibitor 905 Ligand-based -
Cyclin-dependent kinase 4 (CDK4) inhibitor 798 Ligand-based -
Cyclin-dependent kinase (CDK) inhibitor 285 Ligand-based -
EphB2 kinase inhibitor 329 Ligand-based -
Epidermal growth factor receptor kinase (EGFR) inhibitor 318 Ligand-based -
Glycogen synthase kinase-3 (GSK3) inhibitor 153 Ligand-based -
G-protein-coupled receptor kinase (GRK) inhibitor 1268 Ligand-based -
Guanidinoacetate kinase inhibitor 254 Ligand-based -
I kappa B kinase 2 (IKK2) inhibitor 347 Ligand-based -
Inositol-trisphosphate 3-kinase (IP3K) inhibitor 78 Ligand-based -
Lombricine kinase inhibitor 163 Ligand-based -
MAP kinase (MAPK) inhibitor 102 Ligand-based -
N-acylmannosamine kinase inhibitor 935 Ligand-based -
NADH kinase inhibitor 871 Ligand-based -
Opheline kinase inhibitor 875 Ligand-based -
Phosphatidylinositol 3-kinase beta (PI3K-C2 beta) inhibitor 1183 Ligand-based -
Phosphatidylinositol 3-kinase gamma (PI3K-C2 gamma) inhibitor 252 Ligand-based -
Phosphoenolpyruvate carboxykinase (PEPCK) inhibitor 26 Ligand-based -
Platelet derived growth factor receptor kinase (PDGFR) inhibitor 1972 Ligand-based -
Protein kinase CK1 inhibitor 1387 Ligand-based -
Protein kinase B (PKB) inhibitor 1030 Ligand-based -
Protein kinase C eta (PKC) inhibitor 16 Ligand-based -
Protein-serine-threonine kinase inhibitor 213 Ligand-based -
Proto-oncogene tyrosine-protein kinase Fyn inhibitor 481 Ligand-based -
Proto-oncogene tyrosine-protein kinase Kit inhibitor 214 Ligand-based -
Pyridoxal kinase inhibitor 5 Ligand-based -
Raf kinase B inhibitor 38 Ligand-based -
Raf kinase inhibitor 74 Ligand-based -
Rho-associated kinase inhibitor 344 Ligand-based -
Ribosomal protein S6 kinase (S6K) inhibitor 10 Ligand-based -
Shikimate kinase inhibitor 453 Ligand-based -
Smooth muscle myosin light chain kinase (MLCK) inhibitor 627 Ligand-based -
Sphinganine kinase inhibitor 244 Ligand-based -
Sphingosine kinase inhibitor 1119 Ligand-based -
Src kinase inhibitor 200 Ligand-based -
Taurocyamine kinase inhibitor 875 Ligand-based -
Thymidine kinase inhibitor 922 Ligand-based -
Tyrosine kinase inhibitor 1147 Ligand-based -
Urokinase inhibitor 21 Ligand-based -
P21-Activated Kinase 1 (PAK1) 2024 Receptor-based read more
Serine/Threonine-Protein Kinase CHK1 (CHK1) 1946 Receptor-based read more
Proto-Oncogene Tyrosine-Protein Kinase ABL1 2048 Receptor-based read more
Extracellular Signal-Regulated Kinase 2 (ERK2) 2053 Receptor-based read more
Death-Associated Protein Kinase 2 (DAPK-2) 2012 Receptor-based read more
p38 MAP Kinase Alpha 2221 Receptor-based read more
Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) 2235 Receptor-based read more
Aurora B kinase 2069 Receptor-based read more
Janus Kinase 2 (Jak2) 2190 Receptor-based read more
Phosphatidylinositol 3-kinase (PI3K) 2040 Receptor-based read more
3-phosphoinositide-dependent kinase-1 (PDK-1) 1975 Receptor-based read more
Cyclin Dependent Kinase 2 (CDK2) 1281 Receptor-based read more
Glycogen Synthase Kinase-3 (GSK3) 980 Receptor-based read more
Fibroblast growth factor receptor 1 tyrosine kinase (FGFR1K) 1761 Receptor-based read more
cAMP dependent protein kinase (PKA) 1877 Receptor-based read more
C-Jun N-Terminal Kinase 2 (Jnk2, Mapk9) 1774 Receptor-based -
Death-associated protein kinase 1 (DAPK1) 1962 Receptor-based -
Death-associated protein kinase 3 (DAPK3) 1814 Receptor-based -

 

Otava's Target-Focused Libraries collection
Name Number
Kinases 67
Proteases 12
GPCRs 24
Ion channels 3
Disease-based libraries 29
Epigenetic targets 6
Protein-Protein Interaction 2
Peptidomimetic 1
Nuclear Receptors 1
General Activities 127
Other 101

 

 

The libraries (SDF, XLS, PDF format) are available on request. Feel free to contact us or use on-line form below to send an inquiry if you are interested to obtain these libraries or if you need more information.

 

 

 

 

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