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Halogen-Enriched Fragments

Halogen-Enriched Fragment LibraryOur Halogen-Enriched Fragment Library comprises 430 brominated fragments that can explore binding sites for favorable halogen bond interactions to identify unique binding modes that are complementary to those obtained from classical fragment-based screening.
 

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Chelator Fragment Library

Chelator Fragments LibraryFragment-based lead design (FBLD) could be used to identify new metal-binding groups for metalloenzyme inhibitors. Several small-molecule chelators have been shown to effectively inhibit metalloproteins, therefore the design,

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DNMT1 and DNMT3b Libraries

DNMT focused librariesEnzymes involved in the epigenetic regulation of the genome represent promising starting points for therapeutic intervention by small molecules, and DNA methyltransferases (DNMT) are emerging targets for the development of a new class of cancer therapeutics.

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BRD4 Focused Library

Bromodomain-containing Protein 4 (BRD4)Epigenetic regulators are new popular targets for cancer treatment. One of the promising epigenetic drug targets is Bromodomain-containing Protein 4 (BRD4) that binds to acetylated histone lysine residues and stimulates transcriptional elongation leading to expression of growth-promoting genes. 

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Fluorine Fragment Library

Supplier stockNMR is a powerful means for implementing FBDD, and several approaches have been proposed utilizing 1H–15N heteronuclear single quantum coherence as well as one-dimensional 1H and 19F NMR to screen compound mixtures against a target of interest.

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5-HT1B Receptor Library

GPCR focused libraries5-hydroxytryptamine receptors (serotonin receptors , 5-HT receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels found in the central and peripheral nervous

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Diversity Libraries

Diversity LibrariesOtava Diversity Libraries PrimScreen1, PrimScreen2, PrimScreen3, PrimScreen5, PrimScreen10 and PrimScreen15 are prepared by diversity sorting

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General fragments library

Supplier stockUPDATED! The library has been updated by 384 fragments!
The central purpose of this specially designed Fragment Library is to provide

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Catalogs & Booklets
This section contains information on current Otava's products and services (downloadable files in PDF format).




 
HATs Focused Library

Histone Acetyltransferase target-focused libraryPost-translational modifications, such as acetylation or phosphorylation, play a crucial role in the regulation of gene transcription in eukaryotes. Different subtypes of histone acetyltransferases (HATs) catalyze the acetylation of histones on specific lysine residues. 

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Liver X Receptor Beta Library

Liver X receptor β (LXR Beta) modulatorsLiver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids. LXRs function as nuclear cholesterol sensors that are activated in response to elevated intracellular cholesterol levels in multiple cell types.

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HDAC Focused Libraries

GPCR focused librariesClassical histone deacetylases (HDACs classes I, II, and IV) are a promising novel class of epigenetic anti-cancer drug targets. Inhibition of histone deacetylases results in hyperacetylation of histones and modulates gene expression by creating an open chromatin state that leads to expression of previously silenced genes.

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DOT1L Focused Library

GPCR focused librariesHistone methyltransferases are promising epigenetic drug targets. Several drugs that inhibit histone methyltransferases have been developed for anticancer therapy. DOT1L histone H3 methyltransferase methylates lysine 79 on histone H3 (H3K79), within the globular histone domain upon which DNA is wrapped.

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β-Turn Peptidomimetic Library

beta-Turn Peptidomimetic Focused LibraryThe interaction of proteins are critical to nearly all biological processes, including cellular signaling [1]. Our new β-Turn Peptidomimetic Library (520 compounds in total) has been designed 

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PPI Focused libraries

Protein-Protein Interaction Focused LibrariesTargeting protein protein interaction (PPI) is a new challenge to current drug discovery. Due to growing interest in PPI inhibitors we represent focused compound

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CNS Library

CNS Targeted LibraryCNS Compound Library from OTAVA has been designed as a special screening library containing compounds with high blood brain barrier (BBB) permeability.

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Inhibitors
inhib.jpgOTAVA offers a number of INHIBITORS and other biologically active compounds modulating activity of distinct macromolecular targets