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October, 2013 UPDATE:

Screening Compounds

Fragment library


Natural product-like library
Natural product-like library has been designed as a special screening library containing synthetic compounds similar to natural.
 
This library provides additional diversity for drug discovery projects focused on natural compounds. The compounds have been selected from our In-house Stock library by similarity to natural compounds scaffolds. Some scaffolds in the library were filtered by diversity to avoid their prevalence in library. They can be provided as a separate subsets on request.
 
The library contains about 1,400 compounds which are derived from natural compound scaffolds by combinatorial synthesis [1]. It includes polyketides, oxygen heterocycles, simple aromatic compounds, flavonoids, terpenoids, steroids, alkaloids and other derivatives [2, 3].
 
From the library were removed compounds with reactive groups and compounds containing any atom different to O, N, C, H. Halogenated derivatives and compounds with potentially unwanted groups, such as aldehides, quinones also can be obtained on request.
 

All compounds are in stock, cherry-picking is available.

 

The library (DB, SD, XLS, PDF format) as well as the price-list is available on request. Feel free to contact us or use on-line form below to send an inquiry if you are interested to obtain this library or if you need more information.


  1. Armen M Boldi. Libraries from natural product-like scaffolds. J. Current Opinion in Chemical Biology. – 2004 – Vol. 8, P. 281–286
  2. William Running. Chapman and Hall Dictionary of Natural Products on CD-ROM.  J. Chem. Inf. Comput. Sci. - 1993 – Vol. 33, P. 934–935
  3. Gerda Brunhofer, Adyary Fallarero and all. Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: The case of chelerythrine. J. Bioorganic & Medicinal Chemistry. – 2012 – Vol. 20, P. 6669–6679

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