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Publications

PATENTS:

  1. Pat. 86041, 10.12.2013. Low-molecular organic ATP-competitive inhibitors of serine/threonine kinase CK2 based on 4-amino-thieno-[2,3-d]pyrimidine heterocycle. Ostrynska OV, Balanda АО, Bdzhola VG, Kotey ІМ, Кukharenko ОP, Yarmoluk SМ.
  2. Pat. WO2011/065980 (A2), 03.06.2011. Dyes for Analysis of Protein Aggregation. Patton WF, Yarmoluk SM, Pande P, Kovalska V, Dai L, Volkova K, Coleman J, Losytskyy M, Ludlam A, Balanda A, Shen D.
  3. Patent Application US2008091015 A1, 17.04.2008; WO 2008/027821 A1, 06.03.2008. Use of squaraine dyes to visualize protein during separations. Berkelman TR, Yarmoluk SM, Kovalska VB, Losytskyy MYu, Volkova KD.
  4. Pat. US2006207881, 21.09.2006. Detection of polyamino acids using trimethincyanine dyes. Kovalska VB, Kryvorotenko DV, Losytskyy MYu, Nording P, Rueck A, Schoenenberger B, Yarmoluk SM, Wahl F.
  5. Pat. 2004031889, 15.02.2005, Bull. №2, Compound 5-[(4-chlorophenyl)methylidene]-2-(4-oxyanilino)-4,5-dihydrothiazol-4-one, which possess anticancer activity. Lesyk RB, Zimenkovsky BS, Yarmoluk SM, Bdzhola VH, Vovk ОІ. 
  6. Pat. UА68984 А, C07D215/00, 16.08.2004. Application of 4-substituted 3-carboxyquinolines as protein kinase CK2 inhibitors. Sapelkin VM, Lukashov SS, Golub AG, Bdzhola VG, Yakovenko OYa, Yarmoluk SM, Dubinina GG.
  7. Pat. UA69165 А, С07D215/00, 16.08.2004. Application of 4,5,6,7-tetrahalogeno-1,3-isoindolinediones as protein kinase CK2 inhibitors. Golub AG, Yakovenko OYa, Yarmoluk SM, Dubinina GG, Bdzhola VG, Prykhod’ko AO.
  8. Patent Application US2003175988, 18. 09.2003. Method and compounds for the fluorescent labelling of biomolecules and polymer particles. Yarmoluk SM, Kostenko OM, Tolmachev OI, Wolfbeis OS.
  9. Pat. UA 61626A, Cl. C07D207/444, A61K31/40, 19.03.2003.. The structures with antitumor activity among 1-benzyl-3-chloro-4-anilino-2,5-dihydro-1H-2,5-pyrroledione derivatives. Tarnavsky SS, Golovach SM, Dubinina GG, Yarmoluk SM.
 

SELECTED RESEARCH ARTICLES:

  1. Vukomanovic D, Rahman MN, Bilokin Y, Golub AG, Brien JF, Szarek WA, Jia Z, Nakatsu K (2014) In vitro Activation of heme oxygenase-2 by menadione and its analogs. Med Gas Res 4(1):4.
  2. Chekanov MO, Ostrynska OV, Synyugin AR, Bdzhola VG, Yarmoluk SM (2013) Design, synthesis and evaluation of 2-phenylisothiazolidin-3-one-1,1-dioxides as a new class of human protein kinase CK2 inhibitors. J Enzyme Inhib Med Chem 29(3):338-343.
  3. Chekanov MO, Ostrynska OV, Tarnavskyi SS, Synyugin AR, Briukhovetska NV, Bdzhola VG, Pashenko AE, Fokin AA, Yarmoluk SM (2013) Design, synthesis and biological evaluation of 2-aminopyrimidinones and their 6-aza-analogs as a new class of CK2 inhibitors. J Enzyme Inhib Med Chem. 
  4. Volynets G, Bdzhola V, Golub A, Synyugin A, Chekanov M, Kukharenko O, Yarmoluk S (2013) Rational Design of Apoptosis Signal-Regulating Kinase 1 Inhibitors: Discovering Novel Structural Scaffold. Eur J Med Chem 61:104-115.
  5. Golub AG, Bdzhola VG, Ostrynska OV, Kyshenia IV, Sapelkin VM, Prykhod’ko AO, Kukharenko OP, Yarmoluk SM (2013) Discovery and characterization of synthetic 4’-hydroxyflavones – New CK2 inhibitors from flavone family. Bioorg Med Chem 21:6681-6689.
  6. Hunnigan K, Kulkarni SS, Bdzhola VG, Golub AG, Yarmoluk SM, Talele TT (2013) Identification of novel PARP-1 inhibitors by structure-based virtual screening. Bioorg Med Chem Lett 23:5790-5794. 
  7. Golub AG, Gurukumar KR, Basu A, Bdzhola VG, Bilokin Y, Yarmoluk SM, Lee J-C, Talele TT, Nichols DB, Kaushik-Basu N (2012) Discovery of New Scaffolds for Rational Design of HCV NS5B Polymerase Inhibitors. Eur J Med Chem 58:258-264.
  8. Martić S, Tackenburg S, Bilokin Y, Golub A, Bdzhola V, Yarmoluk S, Kraatz HB (2012) Electrochemical screening of the indole/quinolone derivatives as potential protein kinase CK2 inhibitors. Anal Biochem 421(2):617-621.
  9. Golub AG, Bdzhola VG, Kyshenia YV, Sapelkin VM, Prykhod'ko AO, Kukharenko OP, Ostrynska OV, Yarmoluk SM (2011) Structure-based discovery of novel flavonol inhibitors of human protein kinase CK2. Mol Cell Biochem 356(1-2):107-115.
  10. Volynets GP, Chekanov MO, Synyugin AR, Golub AG, Kukharenko OP, Bdzhola VG, Yarmoluk SM (2011) Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1). Med Chem 54(8):2680-2686.
  11. Golub AG, Bdzhola VG, Briukhovetska NV, Balanda AO, Kukharenko OP, Kotey IM, Ostrynska OV, Yarmoluk SM (2011) Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2. Eur J Med Chem 46(3):870-876.
  12. Kramerov AA, Golub AG, Bdzhola VG, Yarmoluk SM, Ahmed K, Bretner M, Ljubimov AV (2011) Treatment of cultured human astrocytes and vascular endothelial cells with protein kinase CK2 inhibitors induces early changes in cell shape and cytoskeleton. Mol Cell Biochem 349(1-2):125-137.
  13. Volynets GP, Bdzhola VG, Kukharenko OP, Yarmoluk SM (2010) Identification of ASK1 small-molecule inhibitors. Ukr Biochim J 82(5): 41-50.
  14. Volynets GP, Bdzhola VG, Yarmoluk SM (2010) Methods of structural bioinformatics. Biotechnology 3(4):9-19.
  15. Grischenko AA, Bdzhola VG, Kukharenko OP, Yarmoluk SM (2009) Search for FGFR1 inhibitors among chromone derivatives. Ukrainica Bioorganica Acta 7(2):64-68.
  16. Volynets GP, Bdzhola VG, Kukharenko OP, Sovetova OV, Yarmoluk SM (2009) Protein kinase ASK1 as potential therapeutic target. Biopolymers and Cell 25(3):169-180.
  17. Golub AG, Yakovenko OYa, Prykhod'ko AO, Lukashov SS, Bdzhola VG, Yarmoluk SM (2008) Evaluation of 4,5,6,7-tetrahalogeno-1H-isoindole-1,3(2H)-diones as inhibitors of human protein kinase CK2. Biochimica et Biophysica Acta 1784(1): 143–149.
  18. Kotey IM, Balanda AO, Bdzhola VG, Lukashov SS, Kukharenko OP, Kharchenko VM, Yarmoluk SM (2008) Synthesis and biologic evaluation of thienopyrimidinones inhibition activity against protein kinase CK2. Ukrainica Bioorganica Acta 6(2):3-9.
  19. Shablykin OV, Kucharenko OP, Iakovenko IN, Yarmoluk SM, Brovarets VS (2008) Search for specific protein kinase СК2 inhibitors and vasoactive compounds among 5-amino-1,3-oxazoles derivatives. Ukrainica Bioorganica Acta 6(1):28-36. 
  20. Volynets GP, Golub AG, Bdzhola VG, Yarmoluk SM (2007) The role of protein kinase CK2 in the regulation of oncogenesis, apoptosis and cellular stress response. Ukrainica Bioorganica Acta 5(2):25-32.
  21. Yakovenko O, Оliferenko A, Bdzhola V, Palyulin V, Zefirov N (2008) Kirchhoff atomic charges fitted to multipole moments: Implementation for a virtual screening system. Journal of Computational Chemistry 29:1332-1343.
  22. Yakovenko OYa, Oliferenko AA, Golub AG, Bdzhola VG, Yarmoluk SM (2007) The new method of distribution integrals evaluations for high throughput virtual screening. Ukrainica Bioorganica Acta 5(1):52-62.
  23. Yakovenko OYa, Golub AG, Bdzhola VG, Yarmoluk SM (2006) Application of distribution function of rotation and translation degrees of freedom for CK2 inhibitors Ki estimation. Ukrainica Bioorganica Acta 4(2):47-55.
  24. Golub AG, Yakovenko OY, Bdzhola VG, Sapelkin VM, Zien P, Yarmoluk SM (2006) Evaluation of 3-Carboxy-4(1H)-quinolones as Inhibitors of Human Protein Kinase CK2. J Med Chem 49(22):6443-6450.
  25. Prykhod’ko AO, Yakovenko OYa, Golub AG, Bdzhola AG, Yarmoluk SM (2005) Evaluation of 4H-4-chromenone derivatives as inhibitors of protein kinase CK2. Biopolymers and cell 21(3):287–292.
  26. Sapelkin VM, Golub AG, Yakovenko OYa, Bdzhola VG, Yarmoluk SM (2005) Search for protein kinase CK2 inhibitors among 3-carboxy-4-aminoquinoline derivatives. Ukrainica Bioorganica Acta 1(1):28–32.
  27. Sapelkin VM, Golub AG, Yakovenko OYa, Bdzhola VG, Yarmoluk SM (2004) Search for casein kinase 2 inhibitors among 4 aminoquinazoline derivatives. Ukrainica Bioorganica Acta 1(1–2):74–79.
  28. Prykhod'ko AO, Dubinina GG, Golovach SM, Yarmoluk SM (2004) Inhibitors of protein kinase CK2. Ukrainica Bioorganica Acta 1(1–2):39–48.
  29. Chekanov MO, Synyugin АR, Lukashov SS, Yarmoluk SM. Synthesis of (1,1-dioxido-3-oxoisothiazolidin-2-yl)-benzenesulfonamides. Ukrainica Bioorganica Acta 6(1):55-60.
  30. Shaitanov PV, Lukashov SS, Turov OV, Yarmoluk SM (2007) Synthesis and structural study of N-substituted-1,7-dithia-4-azaspiro[4.4]nonan-3-one 7,7-dioxides. Ukrainica Bioorganica Acta 5(2):56-61.
  31. Shaitanov PV, Bezugly YuV, Sapelkin VM, Yarmoluk SM (2006) Synthesis of 4-substituted 1-arylhexahydrothieno[3,4-b]pyrazin-2(1H)-one 6,6-dioxides. Ukrainica Bioorganica Acta 4(2):40-46.
  32. Shaitanov PV, Bezugly YuV, Charchenko VM, Lukashov SM, Yarmoluk SM (2005) Synthesis and structural characteristics of 4-(2-phenylethyl)-1,7-dithia-4-azaspiro[4.4]nonan-3-one 7,7-dioxide. Ukrainica Bioorganica Acta 3(2):39-42.
  33. Prykhodko A O, Kobzev SP, Yarmoluk SM (2005) Synthesis of 7-(3-dialkylamino-2-hydroxypropoxy)-3-aryloxychromones. Ukrainica Bioorganica Acta 1(1):33–39.
  34. Prykhod’ko AO, Dubinina GG, Khilya VP, Yarmoluk SM (2004) Antiproliferative activities of some 7-hydroxy-3-aryloxy-2-trifluorometthyl-4H-4-chromenone derivatives against 60 human cancer cell lines. Biopolymers and cell 20(1–2):159–163.
  35. Dubinina GG, Golovach SM, Tarnavsky SS, Yarmoluk SM (2003) Interaction of 7-R-3-R1-7,8-dihydro-2Н,6Н-pyrrolo[3',4':4,5][1,3]thiazolo[3,2-b][1,2,4]triazine-2,6,8-triones with N-nucleophiles. Ukr Khim Zh 69(4):35-39.
  36. Lesyk RB, Zimenkovsky BS, Yarmoluk SM, Subtel’na IYu (2003) Synthesis of potential biologically active substances on the base of 5-carboxymethylidene-2,4-thiazolidinedione. Pharmaceutical journal 1:51–56.
  37. Tarnavsky SS, Dubinina GG, Golovach SM, Yarmoluk SM (2003) The relationship of antitumor activity with the structure of 3-chloro-4-(3-hydroxyanilino)-2,5-dihydropyrrole-2,5-diones. Biopolymers and Cell 19(6):548-552.
  38. Tarnavsky SS, Dubinina GG, Golovach SM, Yarmoluk SM. The search of antitumor activity among derivatives of the 2,5-dihydropyrrole-2,5-dione. Biopolymers and Cell 19(3):287-291.
  39. Sapelkin VM, Ìàkovenko IE, Lukashov SS, Dubinina GG, Yarmoluk SM (2003) Antitumor activity of the 6-substituted derivatives of the 4-alkylaminoquinazolines. Biopolymers and Cell 19(5):467-472.
  40. Arkhipov VV, Prykhod'ko AO, Golub AG, Khilya VP, Yarmoluk SM ((2003) Inhibitors of cyclin-dependent kinases. I. Synthesis of combinatorial libraries of 8-aminomethyl derivatives of 3-aryloxy-7-hydroxychromones and study of their antitumor activity. Biopolymers and Cell 19(2):196-201.
  41. Dubinina GG, Tarnavsky SS, Golovach SM, Yarmoluk SM (2002) Interaction of 3,4-dichloromaleimides with N- and S-nucleophiles. Ukr Khim Zh 68(8):47-51.
  42. Dubinina GG, Volovenko YuM, Yarmoluk SM, Shishkina SV, Shishkin OV (2001) Reaction of N-substituted 3,4-dichloromaleimides with a-mercaptoazaheterocycles. Heterocycles 11:2189-2198.
  43. Alekseeva IV, Palchikovska LI, Shalamay AS, Tarnavsky SS, Nosach LN, Dyachenko NS (1997) The N4-aminoacid derivatives of 6-azacytidine: Syntheses and biological activity. Biopolymers and Cell 13(4):285-290.