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Custom Synthesis

Custom SynthesisOTAVAchemicals, a leading chemical and drug discovery company offers custom synthesis of organic molecules for biotech and pharmaceutical applications. Our small-scale and large-scale chemistry capabilities are able to undertake your projects and work with them right from idea to final production at any scale. A synthetic route literature search is also available (using CAS Sci-Finder, Reaxys and Beilstein databases). The big advantage we have is our operational flexibility and long-standing expertise in synthesis of chemical building blocks, synthesis of compound libraries based on chemical scaffold, custom synthesis of the biologically active compounds (inhibitors/activators, agonists/antagonists etc) and natural product derivatives on a stand-alone basis or as part of an integrated full service solution. The synthetic work can involve extensive application of proprietary cheminformatics, molecular modeling and computational chemistry procedures as well as virtual screening and QSAR in order to select/design compounds or target-focused libraries for various HTS screening and drug discovery projects.

 
Our company supplies over 100 inhibitors used in the study of cell signaling pathways. We are also actively developing our own line of CK2 and ASK1 inhibitors so that our customers can rely on us to be one of the leading suppliers of the newest inhibitors.
 
To cut down on chemical discovery time and cost become our business partner today.

 

Our products are a part of Sigma-Aldrich product catalog

 

 

The service includes synthesis of the following:

  • Starting materials, intermediates, and/or final products
  • Advanced intermediates in drug synthesis
  • Combinatorial chemistry templates
  • Chemical building blocks
  • Reference compounds
  • Hit-to-lead custom libraries
  • Literature and non-literature compounds 
  • Research and development of synthetic pathways for research & commercial molecules and intermediates

 

 

Representative structures from our collection

Fig. 1. Representative structures from our compound collection

 

 

WHY CHOOSE OUR CUSTOM SYNTHESIS SERVICE?

  • Creativity and problem solving in the field of chemistry and biology
  • Weekly progress report
  • Competitive pricing and fast turn-around time
  • Reliability and strict confidentiality
  • Prompt response policy
  • FTE (Full Time Equivalent) & FFS (Fee For Services) projects

 

 
Our company has over 15 years of experience in the area of custom synthesis / contract research and guarantees quality, competitive pricing, and fast turn-around time. We already collaborate with many companies and academic institutions in Europe, United States and Canada, and we hope you will consider working with us.
 
PEOPLE AND FACILITIES
 
Our research facilities are located in North America, namely in Toronto, Kingston and Vaughan (Ontario, Canada) and Europe (Kyiv, Ukraine). We have fully equipped chemical laboratories with well-developed infrastructure and routine access to NMR and LC-MS facilities that allow us to provide any scale of custom synthesis of novel molecules under the supervision of our experienced and talented research team. If you decide to work with us, you would have access to the services of more than 30 chemists 12 of who are PhD scientists with an extensive expertise in laboratory organic synthesis, catalysis, drug and chemical product research, synthesis of amino acids and heterocyclic compounds. We specialize in complex chemical services such as novel synthesis route design and process development, bulk synthesis and specific synthetic intermediates. Our work involves extensive application of proprietary cheminformatics, molecular modeling and computational chemistry procedures as well as virtual screening and QSAR in order to select/design compounds or target-focused libraries for various HTS screening and drug discovery projects. Our team of highly skilled medicinal and computational chemists is ready to facilitate hit identification, target validation or hit-to-lead optimization  projects of any level. The team can work with drug targets including  protein kinases, nuclear receptors, GPCRs, ion channels and anything else you may request.

 

 

SPECIFICATIONS
  • Quality control by NMR and/or GC/LC/MS
  • Purity: 95%+
  • Custom support: structural modification, etc.
  • NMR and LC/MS/MS spectra are available upon request
  • Respond to inquiries within 24 hours
  • Weekly progress reports
  • Confidentiality and intellectual property (IP) protection guarantee
  • FTE (Full Time Equivalent) & FFS (Fee For Services) projects
  • Molecular modeling and computational chemistry procedures with modern state-of-the-art software and algorithms

 

 

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