OTAVAchemicals and Life Chemicals Inc announce research project for C-jun N-terminal Kinase (JNK)
OTAVAchemicals, a chemical and drug discovery technology Company focused on combinatorial chemistry, molecular modeling solutions and development of fluorescent probes, and Life Chemicals, specializing in synthesis of HTS compounds and custom synthesis for life science industries, are pleased to announce the launch of a joint research project aimed at evaluation of new and potent inhibitors of c-Jun N-terminal protein kinase (JNK). Of primary interest in this investigation is a neuronal-specific isoform of JNK (JNK3).
JNK is a stress-activated protein kinase that can be induced by inflammatory cytokines, bacterial endotoxin, osmotic shock, UV radiation and hypoxia. JNK activity is considered to be critical for both immune response and programmed cell death. Therapeutic inhibition of JNK may provide clinical benefit in diseases as diverse as arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, stroke, Parkinson’s disease, ischemic injury, myocardial infarction.
In the framework of this project, OTAVAchemicals will contribute its expertise in molecular modeling and in vitro
screening. The exclusive library of 50 000 compounds and synthetic work will be provided by Life Chemicals. In the near future both Companies are going to join their efforts in lead optimization projects as well.
OTAVAchemicals supplies fine organic chemicals including unique building blocks for combinatorial organic synthesis. We provide compound libraries for screening, custom synthesis, molecular modeling services, targeted compound libraries and protein kinase inhibitors, prescreened anticancer compounds, peptide and chromogenic substrates. We offer design and development of fluorescent probes, kits and reagents.
Established in Kiev, Ukraine, in 1995 as a private small business, Life Chemicals has dynamically expanded and developed to become an internationally recognised producer and supplier of HTS compounds and related services. The Company operates world-wide and its main office is located in Burlington, Canada. This year the Company proudly celebrates its 10 year anniversary as an advanced laboratory to synthesise drug-like and lead-like HTS compounds, targeted libraries, core building blocks and carry out custom synthesis. Life Chemicals employs high skills and abilities of over 80 professionals. It also takes advantage of its co-operation with leading 14 Universities, Academic and industrial laboratories of Ukraine, being the largest exporter of Ukrainian high-tech products.