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12 Billion Novel Molecules: CHEMriya - OTAVA's On-Demand Chemical Space

We are proud to announce the new Chemical Space CHEMriyaTM, created in partnership with BioSolveIT.

The first release of the CHEMriya Space contains 12 billion accessible on-demand molecules, based on thirty-thousand building blocks and 44  in-house reactions. Several multi-component and ring-closure reactions provide a vast chemical diversity with a broad range of molecular scaffolds.

SARS-CoV-2 Main Protease Targeted Library

SARS-CoV-2 Targeted LibrariesThe COVID-19 pandemic caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is a global health emergency. An attractive drug target for this coronavirus is the main protease (3C-like proteinase, 3CLpro, Mpro) because of its essential role in processing the polyproteins that are translated from the viral RNA.

Natural Product-Like Library
Natural Product-Like LibraryNatural Product-Like Library has been designed as a special screening library containing synthetic compounds similar to natural products.
Catechol O‑Methyl Transferase Targeted Library

COMT Targeted LibraryCatechol O‑Methyl Transferase (COMT, HEL-S-98n) degrades catecholamines, catecholestrogens and various drugs having a catechol structure. Mutation of COMT is associated with obsessive-compulsive disorder in men, anxiety phenotypes in women, schizophrenia and other. Developing of the COMT inhibitors is a promising area of neuropsychiatric research. Also catechol‐O‐methyltransferase inhibitors are used as adjuvants to the levodopa/AADC inhibitor therapy for Parkinson's disease treatment.

EZH2 Targeted Library

EZH2 Targeted LibraryEnhancer of zeste homolog 2 (EZH2, ENX-1, ENX1, EZH1, EZH2b, KMT6, KMT6A, WVS, WVS2, enhancer of zeste 2 polycomb repressive complex 2 subunit) is a histone-lysine N-methyltransferase. This enzyme plays an important role in histone methylation and, ultimately, transcriptional repression.

Mutation or over-expression of EZH2 has been linked to many forms of cancer, including bladder, uterine, breast, prostate and renal cancers. EZH2 inhibits genes responsible for suppressing of tumor development, and blocking of it activity may slow tumor growth. Therefore, EZH2 is an attractive target for anti-cancer therapy.

Unsymmetrical Diaryliodonium Salts

Unsymmetrical Diaryliodonium SaltsDiaryliodonium salts are well-known to transfer an aryl group to carbon and heteroatom nucleophiles, and in some cases a base is required [1]. However, transition metal catalysts and supporting ligands are not needed. Moreover, reactions conducted with diaryliodonium salts are operationally simple because they are non-toxic and are not sensitive to air or moisture. Therefore diaryliodonium salts offer an important alternative to metal-catalyzed arylation reactions. Despite these attractive characteristics, a major obstacle to their adoption in chemical synthesis and discovery chemistry has been commercial availability.

S1PR1 Targeted Libraries

S1PR1 Targeted LibrariesSphingosine-1-phosphate receptor 1 (S1PR1, S1P receptor 1, S1P1, endothelial differentiation gene 1, EDG1) is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 has an important role in regulating endothelial cell cytoskeletal structure, migration, vascular maturation and capillary-like network formation. Also S1PR1 signaling is important in the regulation of lymphocyte maturation, migration and trafficking. Abnormal functioning of S1PR1 is associated with cancer and multiple sclerosis. Agonists and antagonists of this receptor may have therapeutic potential in the treatment of such diseases.

RAR-related Orphan Receptor-γ Targeted Library

The Retinoic Acid Receptor-related Orphan Receptor-γ Targeted LibraryThe Retinoic Acid Receptor-related Orphan Receptor-γ (RORγ, RORc, NR1F3, RORG, RZR-GAMMA, RZRG, TOR or IMD42) plays an important role in metabolism, inimmunity and circadian rhythm. Abnormal functioning of RORγ is associated with inflammatory, immune and skin diseases including psoriasis. Antagonists and inverse agonists of this receptor may have therapeutic potential in the treatment of such diseases.


MMP2 Targeted Library

MMP2 Targeted LibrariesThe Matrix metalloproteinase-2 (MMP2, gelatinase A, 72 kDa type IV collagenase) is involved in different functions such as reconstruction of the vasculature, angiogenesis, tissue repair, inflammation, tumor invasion and atherosclerotic plaque rupture. Mutations in the MMP2 gene are associated with Torg-Winchester syndrome, arthritis syndrome, multicentric osteolysis and other pathologies. Therefore, small molecule compounds targeting metalloproteinase-2 may be potential treatment for a variety of diseases related to abnormality functioning of MMP2.

SARMs-Like Library

Selective Androgen Receptor Modulators-Like LibrarySelective androgen receptor modulators (SARMs) act on the androgen receptors (ARs) in a tissue-selective manner and provide an opportunity to promote the beneficial effects of androgens in target tissues with greatly reduced unwanted side-effects. SARMs have been proposed as treatments of choice for various diseases, including muscle-wasting, breast cancer, and osteoporosis.

SARS-CoV-2 Targeted Libraries

SARS-CoV-2 Targeted LibrariesThe pandemic of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a serious global concern for public health with thousands of fatalities. Today, no specific drugs are available to treat this disease. Thus, there remains an urgent need for the development of specific antiviral therapeutics toward SARS-CoV-2.


Viral RNA-dependent RNA Polymerases Targeted Library

Viral RdRps Targeted LibraryRNA-dependent RNA polymerase (RdRP, RDR or RNA replicase) is an enzyme that catalyzes the replication of RNA from an RNA template. RdRPs play a vital role in the growth of RNA viruses and are important targets for antiviral drug development.

PDZ Domain Targeted Library

PDZ Domain Targeted LibraryThe PDZ domains play key roles in anchoring receptor proteins in the membrane to cytoskeletal components, different intracellular signal transduction pathways and many human diseases are associated with their dysregulation.

GASC1 Targeted Library

GASC1 Targeted LibraryLysine-specific demethylase 4C (GASC1, KDM4C, JHDM3C, JMJD2C, TDRD14C, bA146B14.1) is a histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby plays a central role in histone modification. Abnormal functioning of this epigenetic factor is associated with different cancers, including breast cancer. Targeted inhibition of GASC1 in cancer opens new avenues for therapeutic development.

Cathepsin K Targeted Library

Cathepsin K Targeted LibraryCathepsin K (CTSK, CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD) is a lysosomal cysteine protease involved in bone remodeling and resorption. It has a major role in osteoporosis and other bone-related pathologies, cancer, diabetes, obesity and atherosclerosis. Cathepsin K inhibitors show great potential in the treatment of such diseases.

Quaternary Ammonium Salts

Quaternary ammonium saltsOur company is currently offering about 100 new quaternary ammonium salts that could be of interest to your research. All quaternary ammonium salts are in stock, and a full list of the salts in our catalog is available upon request.

Synthetic experience of Otava chemists allows to carry out custom syntheses of even more complex structures of quaternary ammonium salts at a reasonable price.

Renin Targeted Library

Renin Targeted LibraryThe Renin (REN, HNFJ2) is an aspartic protease (also known as an angiotensinogenase). It participates in arterial vasoconstriction and the body's renin–angiotensin–aldosterone system (RAAS) that mediates the volume of extracellular fluid (blood plasma, lymph and interstitial fluid). Thus, it regulates the body's mean arterial blood pressure. An over-active RAAS leads to vasoconstriction and retention of sodium and water. These effects cause hypertension. Therefore, renin inhibitors can be used for the treatment of hypertension.

Kallikrein 6 Targeted Library

Kallikrein 6 Targeted LibrariesKallikrein 6 (KLK6, hK6, Bssp, Klk7, PRSS18, PRSS9, SP59, kallikrein related peptidase 6) plays an important role in various physiological processes. Disorders of KLK6 activity are observed at cancer and neurodegenerative diseases, such as Alzheimer’s disease and multiple sclerosis. Therefore, small molecule compounds modulating kallilrein 6 activity may have a significant therapeutic potential.

Peptidomimetic Libraries

Peptidomimetic LibrariesThe interaction of proteins are critical to nearly all biological processes, including cellular signaling [1]. We offer special screening Peptidomimetic Libraries: β-Turn Peptidomimetic Library containing synthetic compounds which mimic beta-turns of proteins and a-Helix Peptidomimetic Library of compounds mimic alpha-helixes of proteins. These libraries are intended for research and drug discovery projects focused on protein-protein interactions.


Agro-Targeted Libraries

Screening Compounds for Agrochemical DiscoveryTo facilitate a process of finding new agrochemicals within the fields of weed, pest and disease control, OTAVAchemicals design a set of focused libraries of diverse compounds for agrochemical research and development.