1,2-Dihydro-2-naphthalenamine hydrochloride

potent antagonist of the modulatory glycine site of the N-methyl-D-aspartate (NMDA) receptor

OTAVAchemicals Catalogue Number: 7070707014

CAS Registry Number: 81094-64-6

Purity: 95%+ (HPLC)

Ref.: Hathaway et al. A new, potent, conformationally-restricted analog of amphetamine: 2-amino-1,2-dihydronaphthalene. Journal of Medicinal Chemistry (1982), 25, 535-538

Abstract: A new stimulant was prepared as an analog of amphetamine and of 2-aminotetralin. The optical isomers of this amine were obtained by chemical resolution, and the absolute configuration was determined to be (R)-(+) and (S)-(-). (±)-1,2-Dihydro-2-naphthalenamine is approximately one-fourth as potent as (+)-amphetamine as a stimulant in mice. (S)-(-)-1,2-Dihydro-2-naphthalenamine is solely responsible for the stimulant effects of the racemate.

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