N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]-urea
• inhibitor of the Hedgehog Signalling Pathway with IC₅₀ = 70 nM

OTAVA Catalogue Number: 1156359
CAS Registry Number: 330796-24-2
Purity: 97%+ (HPLC)

Ref.: Brunton et al. Potent Inhibitors of the Hedgehog Signaling Pathway. Journal of Medicinal Chemistry (2008), 51, 1108-1110

Abstract: A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR studies of the urea substituent led to a nanomolar Hedgehog antagonist.