N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine (Vandetanib; ZD6474; Zactima)

selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGF2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis. It also inhibits RET-tyrosine kinase activity, an important growth driver in certain types of thyroid cancer

OTAVAchemicals Catalogue Number: 1156355

CAS Registry Number: 443913-73-3

Purity: 95%+ (HPLC)

N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]-urea

inhibitor of the Hedgehog Signalling Pathway with IC₅₀ = 70 nM

OTAVAchemicals Catalogue Number: 1156359

CAS Registry Number: 330796-24-2

Purity: 97%+ (HPLC)

4-[2-[5-methyl-1-(2-naphthyl)pyrazol-3-yl]oxyethyl]morpholine hydrochloride

Selective sigma-1 receptor antagonist Ki = 17.0 nM

Chemical Formula: C20H24ClN3O2

Molecular Weight: 373.9

OTAVAchemicals Catalogue Number:  7070707164

CAS Registry Number:  878141-96-9

Purity:  98%

2-{1-[2-(4-Fluoro-phenyl)-2-oxo-ethyl]-piperidin-4-ylmethyl}-2,3-dihydro-isoindol-1-one

treatment of schizophrenia

Chemical Formula: C22H23FN2O2

Molecular Weight: 366.4

OTAVAchemicals Catalogue Number:   15380609

CAS Registry Number:  359625-79-9

Purity: >95%

4-Nitro-benzoic acid 4-oxo-6-(pyrimidin-2-ylsulfanylmethyl)-4H-pyran-3-yl ester

apelin receptor (APJ) antagonist 

Chemical Formula: C17H11N3O6S

Molecular Weight: 385.4

OTAVAchemicals Catalogue Number:   1024331

CAS Registry Number:  877636-42-5

Purity: 98%

1,2-Dihydro-2-naphthalenamine hydrochloride

potent antagonist of the modulatory glycine site of the N-methyl-D-aspartate (NMDA) receptor

OTAVAchemicals Catalogue Number: 7070707014

CAS Registry Number: 81094-64-6

Purity: 95%+ (HPLC)

ethyl 4-[5-[(2-ethoxypyrimidin-5-yl)methyl]-2-[(4-fluorophenyl)methylsulfanyl]-4-oxo-pyrimidin-1-yl]benzoate

Gprotein-coupled receptor 40 (GPR40; free fatty acid receptor 1; FFAR1) antagonist pIC50 = 5.99, oxytocin receptor antagonist pIC50 = 6.9 

Chemical Formula: C27H25FN4O4S

Molecular Weight: 520.6

OTAVAchemicals Catalogue Number: 7070707009 

CAS Registry Number: 306974-70-9

Purity: 98%+ (HPLC)