Histone deacetylase 1 (HDAC1; also known as GON-10, RPD3, or KDAC1) is a key epigenetic regulator involved in chromatin remodeling and gene expression. Aberrant HDAC1 activity has been implicated in tumorigenesis, and it is widely recognized as a high-value target for cancer therapy due to its role in promoting oncogenic transcriptional programs.

 

The mechanistic target of rapamycin (mTOR; also referred to as FRAP1, RAFT1, or RAPT1) is a central serine/threonine kinase that integrates nutrient and growth factor signals to regulate cell growth, proliferation, metabolism, and autophagy. Hyperactivation of mTOR signaling is a hallmark of various malignancies, contributing to uncontrolled tumor cell survival and resistance to therapy.