N,4-dimethyl-5-[2-(3-methylsulfonylanilino)pyrimidin-4-yl]thiazol-2-amine

Selective CDK2 and CDK9 inhibitor

Chemical Formula: C16H17N5O2S2

Molecular Weight: 375.5

OTAVAchemicals Catalogue Number:  3485491

CAS Registry Number:  870780-40-8

Purity:  95%

12,13-Dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (Arcyriaflavin A)

• Inhibitor of cdk4/cyclin D1 (IC₅₀ = 59 nM). Active against CaM kinase II (IC₅₀ = 25 nM) but displays selectivity over several other kinases in vitro (IC₅₀ values for inhibition of PKA and PKC are > 2 and > 100 μM respectively). Inhibits human cytomegalovirus (HCMV) replication in vitro (IC₅₀ = 200 nM).

OTAVAchemicals Catalogue Number: 7070707137

CAS Registry Number: 118458-54-1

Purity: 95%+ (HPLC)

4-[[[(4-Hydroxy-5-propoxy-2-pyridinyl)methyl]amino]methylene]-6-iodo-1,3(2H,4H)-isoquinolinedione

Potent and selective inhibitors of the Cyclin-Dependent Kinase 4

OTAVAchemicals Catalogue Number: 7070707068

CAS Registry Number: 943746-57-4

Purity: 97%

2-Bromo-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione

• A cell-permeable, unsymmetrical indolocarbazole compound that displays antiproliferative properties. Acts as a potent, selective, and ATP-competitive inhibitor of Cdk4/D1 (IC₅₀ = 76 nM)

OTAVAchemicals Catalogue Number: 7070707035

CAS Registry Number: 546102-60-7

Purity: 97% (HPLC)

4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol

Cdk9 Inhibitor II is an ATP-competitive inhibitor of Cdk9 and moderate inhibitor of similar enzymes. Cdk9 Inhibitor II is an ATP-competitive inhibitor of cyclin-dependent kinase 9 (Cdk9; IC50 = 350 nM) and moderate inhibitor of similar enzymes including Cdk2-cyclin E. In the HT-29 cancer cell line, Cdk9 inhibitor II was observed to attenuate the frequency of the S-phase

OTAVAchemicals Catalogue Number: 7020402317

CAS Registry Number: 140651-18-9

Purity: 97%+ (HPLC)

4-[[2-[(1-benzylindol-5-yl)amino]-6-(ethylamino)pyrimidin-4-yl]amino]cyclohexanol

Cyclin-dependent kinase 4/6 specific inhibitor, Cdk4/cyclin D1 IC50 = 1.5 µM, Cdk6/cyclin D1 IC50 = 5.6 µM

OTAVAchemicals Catalogue Number: 1112092

CAS Registry Number: 359886-84-3

Purity: 98% (HPLC)