N-[2-methyl-5-({[(3,4,5-trimethoxybenzoyl)amino]carbonothioyl}amino)phenyl]biphenyl-4-carboxamide

Molecular Weight: 555.6579

OTAVAchemicals Catalogue Number: 7070707159

CAS Registry Number: 1263132-08-6

Purity: 99% (HPLC)

N-[2-methyl-5-({[(3,4,5-trimethoxybenzoyl)amino]carbonyl}amino)phenyl]biphenyl-4-carboxamide

An inhibitor of the Hh signaling pathway (IC50 =  6 nM) 

Molecular Weight: 539.5933

OTAVAchemicals Catalogue Number: 7070707158

CAS Registry Number: 1359944-56-1

Purity: 99% (HPLC)

N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]-urea

inhibitor of the Hedgehog Signalling Pathway with IC₅₀ = 70 nM

OTAVAchemicals Catalogue Number: 1156359

CAS Registry Number: 330796-24-2

Purity: 97%+ (HPLC)

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine

Hedgehog signaling inhibitor that prevents Gli-dependent transcriptional activity (IC₅₀ = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI₅₀ = 3 - 21 nM)

and in human xenografts in vivo. Inhibits alcohol dehydrogenase 7 (Adh7) (IC₅₀ = 210 nM) and acts as a microtubule depolymerizing agent in vitro

OTAVAchemicals Catalogue Number: 7211760148

CAS Registry Number: 315703-52-7

Purity: 98% (HPLC)