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Agonists


0127440673

E-4-hydroxy-N-4-isopropylbenzylidene benzohydrazide, 4-hydroxy-benzoic acid 4-isopropyl-benzylidene-hydrazide;

2-[[4-(1-Methylethyl)phenyl]methylene]hydrazide 4-hydroxybenzoic acid

GSK 4716 is an Estrogen-related receptors ERRß and ERRa agonist with minimal activity for ERRa, ERa and ERß

Chemical Formula: C17H18N2O2

Molecular Weight: 282.3

OTAVAchemicals Catalogue Number: 0127440673

CAS Registry Number: 101574-65-6

Purity: 98%+ (HPLC)

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7211760086

Autophagy_Inducer

N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine (STF-62247)

selectively induces cell death in VHL-deficient cells

OTAVAchemicals Catalogue Number: 7211760086

CAS Registry Number: 315702-99-9

Purity: 95%+ (HPLC)

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7114471128

Potent_and_positive_allosteric_mGlu4_agonist

(±)-cis-2-{[(3,5-dichlorophenyl)amino]carbonyl}cyclohexanecarboxylic acid ((1R,2S)-rel-2-[[(3,5-dichlorophenyl)amino]carbonyl]-cyclohexanecarboxylic acid; VU0155041)

• Positive allosteric selective modulator at mGluR4 (EC50 values are 798 nM and 693 nM at human and rat mGluR4 receptors respectively). It has advantages over PHCCC (Asc-043) as it is water soluble and more potent. Active in behavioural models of Parkinsons Disease
Relative stereochemistry

OTAVAchemicals Catalogue Number: 7114471128

CAS Registry Number: 1093757-42-6

CAS Registry Number: 1259372-69-4 (sodium salt)

Purity: 95%+ (HPLC)

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7070707134

Histamine_H4_receptor_agonist

2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester (S-(2-guanidylethyl)-isothiourea; VUF 8430 dihydrobromide) 

VUF 8430 dihydrobromide is a potent histamine H4 receptor full agonist (pEC50 = 7.3), high affinity (pKi = 7.5)

OTAVAchemicals Catalogue Number: 7070707134

CAS Registry Number: 100130-32-3

CAS Registry Number: 98021-17-1 (free base)

Purity: 97%+

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7070707030

Partial_dopamine_D2_agonist_5-HT1A_agonist

7-[4-([1,1'-Biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone (Bifeprunox)

a potent dopamine D2-like and 5-HT1A receptor partial agonist with pKis of 7.19 and 8.83 for cortex 5-HT1A and striatum D2, and a pEC50 of 6.37 for hippocampus 5-HT1A, respectively.

Bifeprunox is an antipsychotic for the research of schizophrenia

OTAVAchemicals Catalogue Number: 7070707030

CAS Registry Number: 350992-10-8

Purity: 97%+ (HPLC)

 

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