3-[(6,7-Dimethoxy-4-quinazolinyl)amino]-phenol

Inhibitor of IgE-mediated mast cell responses. Tau-Tubulin Kinase 1 inhibitor, phosphorylated TTBK1 KD = 0.46 µM, nonphosphorylated TTBK1 KD = 0.24 µM.

REarranged during Transfection (RET) kinase inhibitor, IC50 = 5 nM, KDR (VEGFR2) kinase inhibitor, IC50 = 66 nM

OTAVAchemicals Catalogue Number: 7015070102

CAS Registry Number: 211555-08-7

Purity: 97% (HPLC)

7-[4-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-heptanoic acid hydroxyamide

Potent multi-acting HDAC, EGFR, and HER2 inhibitor.

HDAC enzyme assay IC50 = 6.5 nM, EGFR = 3.1 nM, HER2 = 19.0 nM

OTAVAchemicals Catalogue Number:  7070707144

CAS Registry Number:  1012054-55-5

Purity:  95%+

(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-(5-{2-[(pyridin-4-ylmethyl)-amino]-phenyl}-[1,3,4]oxadiazol-2-yl)-amine

 Tubulin polymerization inhibitor ITP IC50 =  1.09 µM, G2/M transition block EC50 = 0.009 µM,

VEFGR-2 enzyme IC50 = 0.21 µM, VEGFR-2 cell IC50 = 0.11 µM

OTAVAchemicals Catalogue Number:  7070707143

CAS Registry Number:  830333-53-4

Purity:  95%+

3-[(4-Bromo-2,6-difluorophenyl)methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]-4-isothiazolecarboxamide (CP-547632)

potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC₅₀ = 11 and 9 nM, respectively). It is selective relative to epidermal growth factor receptor, platelet-derived growth factor ß, and other related TKs. It also inhibits VEGF-stimulated autophosphorylation of VEGFR-2 in a whole cell assay with an IC₅₀ value of 6 nM

OTAVAchemicals Catalogue Number: 1156353

CAS Registry Number: 252003-65-9

Purity: 95%+ (HPLC)

5-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid (NSC 702827; SU 6668; TSU 68)

ATP-competitive PDGFR, VEGF and FGFR inhibitor (IC₅₀ values are 0.06, 2.43, 3.04 and > 100 μM at PDGFRβ, VEGFR2, FGFR1 and EGFR respectively). Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC₅₀ values are 0.41, 9.3 and 16.5 μM for VEGF, FGF and PDGF-stimulated growth respectively) and induces > 75% growth inhibition against a broad range of tumor types in vivo.

OTAVAchemicals Catalogue Number: 1156360

CAS Registry Number: 252916-29-3

Purity: 95%+ (HPLC)

4-((2-((4-Chloro-3-((((2S)-1-methyl-2-pyrrolidinyl)methyl)oxy)-phenyl)amino)-1,3-benzoxazol-5-yl)oxy)-N-methyl-2-pyridinecarboxamide

IC50 = 28 nM

OTAVAchemicals Catalogue Number: 1156358

CAS Registry Number: 769960-39-6

Purity: 95%+ (HPLC)

4-[(4'-Chloro-2'-fluoro)phenylamino]-6,7-dimethoxyquinazoline hydrochloride (ZM 306416)

OTAVAchemicals Catalogue Number: 7070707147

CAS Registry Number: 690206-97-4

Purity: 95%+ (HPLC)

4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline (AZD2171; Cediranib)

an oral tyrosine kinase inhibitor of all of the VEGF receptors (VEGFR1, VEGFR2, VEGFR3), as well as KIT and (less potently) PDGFRA and PDGFRB

OTAVAchemicals Catalogue Number: 1156354

CAS Registry Number: 288383-20-0

Purity: 95%+ (HPLC)

N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine (Vandetanib; ZD6474; Zactima)

selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGF2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis. It also inhibits RET-tyrosine kinase activity, an important growth driver in certain types of thyroid cancer

OTAVAchemicals Catalogue Number: 1156355

CAS Registry Number: 443913-73-3

Purity: 95%+ (HPLC)